Neurological sleep medicine research group

Our research relates to basic questions of sleep physiology and selected aspects of clinical neurological sleep medicine. More specifically, we are focussing on the neuronal organisation of the motor system in NonREM and REM sleep in both health and disease. To this end we are using a broad range of established neurophysiological methods including stimulation techniques (e.g. transcranial magnetic stimulation, F-waves) as well as signal analysis (e.g. coherence, directed transfer function). Our interest in clinically related research encompasses the various Non-REM and REM parasomnias, disturbed sleep in neurological movement disorders, narcolepsy and sleep-related epilepsies.

Collaborations

– Peter Brown, Functional Neurosurgery and Experimental Neurology Group, University of Oxford, United Kingdom

– Andrew Sharott, MRC Anatomical Neuropharmacology Unit, University of Oxford, United Kingdom

– Ramin Khatami, Centre for Sleep Medicine, Barmelweid, Switzerland

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Selected Publications

Salih F, Sharott A, Khatami R, Trottenberg T, Kupsch A, Schneider GH, Brown P, Grosse P.

Functional coupling between motor cortex and globus pallidus in human non-REM sleep. Journal of Physiology 2009;587:1071-1086.

Salih F, Grosse P.

Is the motor system at rest while we are sleeping? Physiology News 2009;76: 15-17.

Salih F, Kliengebiel R, Zschenderlein R, Grosse P.

Acoustic sleep starts with sleep-onset insomnia related to a brainstem lesion, Neurology 2008;70:1935-1937

Salih F, Grosse P. Transkranielle Magnetstimulation und Schlaf, in U Ziemann and H Siebner (Hrsg.).

Transkranielle Magnetstimulation. Heidelberg: Springer, 2007, S. 477-486.

Salih F, Khatami R, Steinheimer S, Kretz R, Schmitz B, Grosse P.

A hypothesis how Non-REM sleep might promote seizures in partial epilepsies: a transcranial magnetic stimulation study. Epilepsia 2007;48:1538-1542.

Salih F, Khatami R, Steinheimer S, Hummel O, Kühn A, Grosse P.

Inhibitory and excitatory intracortical circuits across the human sleep-wake cycle using paired-pulse TMS. Journal of Physiology 2005;565:695-701.

Grosse P, Khatami R, Salih F, Kühn A, Meyer B-U.

Excitability of the corticospinal system in natural human sleep as assessed by transcranial magnetic stimulation Neurology 2002;59:1988-1991.

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